Wool, Synthetic, Or Merino? The Best Materials For Anti-Blister Socks

However, even after mixing them with synthetic materials, theyre still not as great as merino wool and ordinary wool for wet and cold weather. Choosing the right socks?. We break down the differences between merino wool and synthetic base layers, including warmth, breathability, moisture wicking, odor resistance, comfort, durability, and more. If youre looking for a new base layer, theres a good chance youre considering either a merino wool or synthetic design. They are the top two material choices for a reason,.