In the proposed review, we report 158 natural product inhibitors of cox during 2006 to 2019 belonging to various secondary metabolite classes such as alkaloids, terpenoids, polyphenols. Looking forward, coxibs are now being studied for repurposing, given their possible implications in the management of a myriad of diseases, including cancer, epilepsy, psychiatric disorders,. Innate inflammation beyond a threshold is a significant problem involved in cardiovascular diseases, cancer, and many other chronic conditions. Cyclooxygenase (cox) enzymes are key inflammatory markers as they catalyze prostaglandins production and are.
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